Use Of Collagenase In Treatment Of Diabetes

Currently there is no cure for diabetes. The goal of diabetes treatment is to keep the blood sugar level under control with low glycemic diet and diabetes medications. Stopping treatment causes abnormal increase in the blood sugar level within a short time.

Use Of Collagenase In Treatment Of Diabetes

Even when diabetics are on hypoglycemic drugs or insulin, their blood sugar levels should be monitored regularly to prevent hypoglycemia and other side effects of diabetes drugs. Your doctor may change the dosage or the drug to ensure that your blood sugar level remains in the normal range. Therefore, current diabetes treatment requires diabetics to remain under the observation of doctors and health care providers throughout their lives.

Collagenase Use For Diabetes Treatment

Collagenase treatment of diabetes has been developed to provide permanent or long-term relief from diabetes. Although therapy with collagenase is still in the experimental stage, preliminary evidences from laboratory studies suggest effectiveness of the therapy in treating diabetes.

How Collagenase Treatment Cures Diabetes

Diabetes occurs when sufficient insulin is not present in the body to enable the tissues to absorb glucose from the blood. Insulin is produced by the beta cells of the pancreas. Degeneration of the insulin producing pancreatic cells reduces the insulin level in the body. Medications used for improving the blood sugar level work either by introducing insulin to the blood or stimulating the pancreas to increase insulin secretion.

Transplanting healthy islet cells to the pancreas of a diabetic person can provide a permanent solution to diabetes. To ensure sufficient insulin production, about a million islets should be isolated from the pancreas. A single donor pancreas is not sufficient for supplying the large number of islet cells. Two donor pancreases can provide the large number of islet cells for reducing dependence of the diabetic patient on insulin medications.

Collagenase is a type of enzyme, which is injected into the donor pancreas to dissolve the peptide bonds of the cells. Peptide bonds bind the cells to each other. Once the peptide bonds are digested by the collagenase solution, the islet cells are separated from the pancreas. The isolated islet cells are then ready for transplantation.

Using collagenase for harvesting islet cells helps to isolate the cells from an organ without affecting the functions of the cells. After transplantation of the islets cells, immunosuppressive medications are used to prevent rejection of the transplanted islets.

How Collagenase Treats Diabetic Foot Ulcer

While use of collagenase for islets transplantation is still in the experimental stage, scientists have found evidence to support the use of collagenase for treating diabetic foot ulcers, a severe diabetes complication. Foot ulcer is a major cause of foot amputation in diabetics. Collagenase is combined with a topical antibiotic and applied to the wound.

By breaking up the dead cells, the enzyme helps to remove the worn out tissues and skin from the site of the wound, thereby allowing the antibiotic to reach easily the deeper layers of the skin. Poor healing of wounds in diabetics can be resolved by using collagenase as a vehicle for delivering medication. Irritation, redness and pain in the treated area are possible side effects of collagenase ointment.

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